46 YEAR OLD MALE WITH ALTERED SENSORIUM

G SUHITHA GNANESWAR 

HALL TICKET NO - 1701006047 

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I have been given this case to solve in an attempt to understand the topic of " Patient clinical data analysis" to develop my competancy in reading and comprehending clinical data including history, clinical finding, investigations and come up with a  diagnosis and treatment plan.

SHORT CASE:

A 46 year old male came to casuality with chief complaints of 

-burning micturition since 10days

-vomiting since 2days (3-4 episodes)

-giddiness and deviation of mouth since 1day


HISTORY OF PRESENTING ILLNESS

Patient was apparently asymptomatic 10years back, he complained of polyuria for which he was diagnosed with Type 2 diabetes mellitus he was started on OHAs, 3years back OHAs were converted to insulin.

20days back he developed vomiting containing food particles, non bilious,non foul smelling(3-4 episodes),later he complained of giddiness and deviation of mouth for which he was brought to our hospital and his GRBS was recorded high value for which he was given NPH 10U and HAI 10U.

No history of fever/cough/cold 

No significant history of UTIs




PAST HISTORY 

10years back patient complained of polyuria for which he was diagnosed with Type 2 Diabetes Mellitus, he was started on oral hypoglycemic agents(OHA). 3years back OHAs were replaced by Insulin. 3years ago he underwent a cataract surgery. 1year ago he had injury to his right leg, which gradually progressed to non healing ulcer extending upto below knee and ended with undergoing below knee amputation due to developement of wet gangrene.

Delayed wound healing was present- it took 2months to heal

Not a k/c/o Hypertension, Epilepsy,Tuberculosis, Thyroid

Not on any medication

No history of blood transfusion 

PERSONAL HISTORY 

Diet - Mixed

Appetite- normal

Sleep- Adequate 

Bowel and bladder- Regular

Micturition- burning micturition present

Habits/Addiction:

Alcohol- 

Not consuming alcohol since 1 yr.

Previously (1yr back) Regular consumption of alcohol, about 90mL whiskey consumed almost daily.Also 1 month on & off  consumption pattern previously present 

FAMILY HISTORY 

not significant 

VITALS

Vitals @ Admission:

BP: 110/80 mmHg

HR: 98 bpm

RR: 18 cpm

TEMP: 101F

SpO2: 98% on RA

GRBS: 124 mg/dL

General Examination:

Pallor present 

No- icterus,cyanosis,clubbing,koilonychia, lymphadenopathy

No dehydration












Systemic Examination:

CVS: S1S2 heard, No murmurs

RS: BAE+,NVBS

P/A: Soft, Non tender

CNS:  

Higher function test: 

Pt is having altered sensorium 

Slurred speech 

Not Orientated to time place person.

Memory couldn't be elicited as pt is in altered sensorium 

Cranial nerves : intact 

Motor system :   

1, Bulk :                    right.                    Left 

Upperlimb          normal.                Normal

Lowerlimb.        thigh -N.                Normal 

                          Below knee amputated on R side

2,  Tone : 

Upperlimb.          Normal.             Normal 

Lowerlimb.         Normal.             Normal 


 3, Power :

Neck:. Normal 

Trunk:. Normal

         Upper limb       5                        5

         Lower limb       5                        5 

 4, Reflexes 

                                     Right           Left 


                Biceps           2+.                  2+


                Triceps          2+                    2+


               Supinator        2+                   2+


                Knee               2+.                 2+


               Ankle               2+.                2+


         Planter reflex    Amputated   flexion

Sensory system : normal 

Meaningal signs  : negative


INVESTIGATIONS 

ON DAY OF ADMISSION 

HEMOGRAM:
Hemoglobin: 8.0 g/dl
TLC: 22900 cells/cumm
N/L/E/M: 89/03/1/7
Platelet: 1.50
MCV: 73.5
MCH: 27.2
RDW: 11.7%
PCV: 21.6
RBC COUNT: 2.94

ELECTROLYTES:
Na: 124
Cl: 80
K: 2.6

RENAL FUNCTION TESTS
Urea: 129
Creatinine: 4.7
Urine for ketone bodies- negative 
LIVER FUNCTION TESTS
Total Bilirubin: 1.52
Direct Bilirubin: 0.50
SGOT:21
ALT:10
ALP:275
Total Protein: 5.6
Albumin: 2.3
A/G: 0.72

X ray 

ON DAY 2
LDH- 192
24hr Urinary protein- 434
24hrs Urinary creatinine- 0.5


 Culture report- klebsiella pneumonia positive 



ON DAY 3
Hemoglobin- 6.8g%
TLC- 22,500cells/cumm
Platelets- 1.4lakhs/cu.mm

Urea- 155mg/dl
Creatinine- 4.7
Uric acid- 7.1
Phosphorus- 2.0
Sodium- 126
Potassium- 2.6
Chloride- 87

ON DAY 4
Hemoglobin- 7.2
TLC- 17,409
Platelet count- 1.5

Urea- 162
Uric acid- 5.0
Sodium- 125
Chloride- 88

ON DAY 5

ON DAY 6



ON DAY 7
Hb- 7
TLC- 22,000
Platelet count- 26,000
Urea- 144
Creatinine - 4.8
Uric acid-9.1
Phosphorus- 4.8
Sodium- 135
Potassium- 4.3
Chloride- 98
Fasting blood sugar- 149

ON DAY 8
Hb- 6.4
TLC- 14,700
Platelet count- 6000
Urea - 149
Creatinine- 4.4
Uric acid- 9.2

Provisional Diagnosis: 
Right emphysematous pyelonephiritis and left acute pyelonephiritis and encephalopathy secondary to sepsis.
H/o of Type 2 Diabetes mellitus since 10years

Treatment:

Day 1 to Day 3:
INJ. MEROPENEM 500mg IV BD
INJ. ZOFER 4mg IV TID
INJ. PAN 40mg IV OD
IV Fluids- NS,RL @ 100 mL/hr
BP/HR/RR/SpO2 charting
Temp charting 4th hrly
RT feeds- 2nd hrly 100 mL water

Day 4
INJ. MEROPENEM 500mg IV BD
INJ. ZOFER 4mg IV TID
INJ. RANTAC 50mg IV OD
INJ. KCl 2 Amp in 500 mL NS over 4.5 hrs infusion
IV Fluids- NS,RL @ 100 mL/hr
SYP. POTCHLOR 10 mL in 1 glass of water TID
SYP. MUCAINE GEL 10 mL PO TID
7 point profile
BP/HR/RR/SpO2 charting
Temp charting 4th hrly
RT feeds- 2nd hrly 100 mL water

Day 5 to Day 10:
INJ. MEROPENEM 500mg IV BD (Day 6)
INJ. ZOFER 4mg IV TID
INJ. RANTAC 50mg IV OD
INJ. LASIX 40 mg IV BD
IV Fluids- NS,RL @ 100 mL/hr
SYP. MUCAINE GEL 10 mL PO TID
GRBS 7 point profile
INJ.HAI SC TID ACC to GRBS
TAB.DOLO 650 mg SOS
BP/HR/RR/SpO2 charting
Temp charting 4th hrly

Day 11:
INJ. COLISTIN 2.25 MU IV OD(Day 4)
INJ. ZOFER 4mg IV TID
INJ. RANTAC 50mg IV OD
INJ. LASIX 40 mg IV BD
IV Fluids- NS,RL @ 100 mL/hr
SYP. MUCAINE GEL 10 mL PO TID
GRBS 7 point profile
INJ.HAI SC TID ACC to GRBS
TAB.DOLO 650 mg SOS

Day 12:
SDP Transfusion done I/v/o low platelet count 
Pre transfusion counts:
Hb:6.2 g/dL
TLC:14700
PLt:6000

Post transfusion counts:
Hb:6.4
TLC:13700
PLt:50000

INJ. COLISTIN 2.25 MU IV OD(Day 5)
INJ. ZOFER 4mg IV TID
INJ. RANTAC 50mg IV OD
INJ. LASIX 40 mg IV BD
IV Fluids- NS,RL @ 100 mL/hr
SYP. MUCAINE GEL 10 mL PO TID
GRBS 7 point profile
INJ.HAI SC TID ACC to GRBS
TAB.DOLO 650 mg SOS

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